The HMM calibrate tool reads a HMM profile file, scores a large number of synthesized random sequences with it, fits an extreme value distribution (EVD) to the histogram of those scores, and re-saves the hmm file including the EVD parameters.
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The HMM calibrate tool reads a HMM profile file, scores a large number of synthesized random sequences with it, fits an extreme value distribution (EVD) to the histogram of those scores, and re-saves the hmm file including the EVD parameters.
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