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The Sequence Annotations settings allows to use upper/lower case annotations during the file reading process.

Format options:

  1. Don’t use case annotations (default mode) — usual sequence reading and writing.
  2. Use lower case annotation — sequences are read and annotations with names lower_case are added. When these sequences are written to file then the case becomes like original the file case (the case is saved).
  3. Use upper case annotation — there is a similar behavior but with “upper_case” annotations.